Cushing, Cortisol, and Cardiovascular Disease

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Cushing, cortisol, and cardiovascular disease.

Cushing's syndrome of glucocorticoid excess is named after the eminent Boston neurosurgeon Harvey W. Cushing (1869-1939). The recognition that glucocorticoid excess produces hypertension led to examination of the role of cortisol in essential hypertension, but it is only over the last decade that evidence has emerged to support the concept. Despite the widespread assumption that cortisol raises...

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relation between pre-and post-dexamethasone test cortisol values in cushing's disease

introduction the dexamethasone test has been widely used for diagnosing hypercortisolism. materials and methods we assessed the relationship between the basal and suppressed cortisol values in urine and plasma during a low-dose dexamethasone test in patients with proved cushing&apos;s disease. results a statistically highly significant correlation was found (for urine cortisol: r = 0.66, p <0.0...

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Adrenocorticotropic Hormone-Independent Cushing Syndrome with Bilateral Cortisol-Secreting Adenomas

A 48-year-old woman was incidentally found to have bilateral adrenal masses, 2.8 cm in diameter on the right, and 2.3 cm and 1.7 cm in diameter on the left, by abdominal computed tomography. The patient had a medical history of hypertension, which was not being controlled by carvedilol, at a dose of 25 mg daily. She presented with signs and symptoms that suggested Cushing Syndrome. We diagnosed...

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Hair cortisol in the evaluation of Cushing syndrome.

PURPOSE Hair cortisol evaluation has been used to help detect patients with suspected Cushing syndrome. Our goal was to correlate segmental hair cortisol with biochemical testing in patients with Cushing syndrome and controls. This study was a prospective analysis of hair cortisol in confirmed Cushing syndrome cases over 16 months. METHODS Thirty-six subjects (26.5 ± 18.9 years, 75% female, a...

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Dilated Cardiomyopathy Revealing Cushing Disease

Cardiovascular impairments are frequent in Cushing’s syndrome and the hypercortisolism can result in cardiac structural and functional changes that lead in rare cases to dilated cardiomyopathy (DCM). Such cardiac impairment may be reversible in response to a eucortisolaemic state. A 43-year-old man with a medical past of hypertension and history of smoking presented to the emergency department ...

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ژورنال

عنوان ژورنال: Hypertension

سال: 2000

ISSN: 0194-911X,1524-4563

DOI: 10.1161/01.hyp.36.5.912